Objective: The aim of this study was to compare the effects of telmisartan and valsartan on blood pressure and serum leptin in hypertensive type 2 diabetes Mellitus patients. Study design:A randomized control comparative clinical trial with open label design. Study period: From 1st February, 2012 to 30th March, 2013. Patients and method: Eighty eight type 2 diabetic hypertensive patients were randomly assigned to received either telmisartan (n = 46) or valsartan (n = 42) with body mass index (BMI) 31.52±4.73 kg/m², 30.39±3.95 kg/m² respectivly. Forty one diabetic normotensive patients (n=41), age, sex, BMI, duration of diabetic disease, duration of diabetic treatment matched to the diabetic hypertensive patients groups were kept as control group. blood pressure (BP), leptin levels were measured at baseline and after 2 months of treatment. Results: The study showed a significant higher systolic blood pressure (SBP), diastolic blood pressure (DBP) and serum leptin in the diabetic hyperte