In developing countries, access to essential medicines is a common issue. Generic drug prescribing and drug prescribed from essential drug lists (EDL) minimizes the error in adopting pharmacotherapy approaches and improves the safe and effective use of drugs. This study aimed to assess the consultants’ prescribing patterns in a teaching hospital. A prospective descriptive study was carried out from January to March 2020. The systematic random sampling technique was used for collecting prescriptions from consultants in outpatient pharmacy departments (OPD) of the hospital. The collected data was assessed using the World health organization (WHO) core prescribing indicators and their standard guidelines. A total of 639 prescriptions were collected prospectively in which 3136 drugs were prescribed (Mean; 4.9) in prescriptions. The majority of the drugs, 77.7% (n = 2438) were prescribed from EDL while 6.1% (n = 194) of drugs by generic names. Antibiotics were prescribed in 9.6% (n = 303),