Background: Self-medication with over-the-counter products has dramatically increased following coronavirus disease of 2019 pandemic. For safe public use of these products, Pharmacy and Doctor of Pharmacy students are expected to have proper knowledge and perception towards these products dispensing and associated interactions. Objectives: A cross-sectional survey was developed to assess Pharmacy and Doctor of Pharmacy students’ knowledge and perception towards drug interactions of over the counter products. Methods: Data were collected using a self-administered questionnaire and statistically analyzed. Descriptive statistics (frequency) were analyzed for participants’ demographics. Multivariable logistic regression analysis was used to determine the association between over the counter products and relevant interactions with medications to treat chronic illnesses. A P value < 0.05 was used to determine statistical significance. Results: Responses were 411 and only 389 were included.