Renal failure is an increasing problem representing a great health challenge. It affects males more than females and blacks more than whites. Despite the anatomical gender differences in urethra might match with occurrence of urinary infection in women more than in men, it has been stated that the reverse is the true. Renal infection and even failure are more encountered in men. The reason for such gender discrepancies regarding renal failure is not yet clearly understood. In this short article, we aimed to suggest a probable answer for the following confusing question: Why does chronic renal failure affect males more often than females?