Aims: To clarify the nephrotoxic effect of paracetamol in adult male albino rats. In this study, fourteen adult male albino rats were divided equally into two groups; Control group and paracetamol-treated group. Kidney specimens were processed for biochemical and histological analysis. Administration of paracetamol revealed a noticeable deterioration of both biochemical and histological changes detected in the paracetamol-treated group. The biological changes were in the form of significant increase in serum urea and creatinine levels. The histological changes markedly affected the tubular system; the proximal and distal convoluted tubules showed marked degeneration, dense nuclear staining, cytoplasmic vacuolization and partial loss of the brush borders. Most tubules were dilated, irregular and filled with hyaline casts. Paracetamol made biochemical and histo-pathological changes in the rats kidneys.