Identification of Novel Inhibitors for Pim-1 Kinase using Pharmacophore Modeling Based on a Novel Method for Selecting Pharmacophore Generation Subsets.
Researcher Name
lubna swellmeen
Name Of Journal
Journal of Computer-Aided Molecular Design
Volume No.
10.1007/s10822-015-9887-7
Date Of Publication
2015.12
Abstract
Targeting Proviral integration-site of murine Moloney leukemia virus 1 kinase, hereafter called Pim-1 kinase, is a promising strategy for treating different kinds of human cancer. Headed for this a total list of 328 formerly reported Pim-1 kinase inhibitors has been explored and divided based on the pharmacophoric features of the most active molecules into 10 subsets projected to represent potential active binding manners accessible to ligands within the binding pocket of Pim-1 kinase. Discovery
