This study explored the effectiveness of Blended Learning, hereafter (BL) on students’ academic achievement, interaction and satisfaction in higher education. The Integrated M-Learning and ELearning system, (IMELS) was utilized on a sample of students (n = 52) who attended Artificial Intelligent course at a large urban college in Jordan. The pretest/post-test design was used to investigate the students’ academic achievement, interaction and satisfaction. ANOVA test was conducted to compare the achievement scores between the BL with IMELS group and face-to-face learning group. The post-test revealed a significant difference between the two groups in favour of the treatment group. Findings also showed that interaction types were positively associated with satisfaction of the students exposed to the IMELS in favour of learner-instructor interaction. This study has contributed to a better understanding of new technologies like IMELS in BL environment,